| DaTSCAN Home Page | |||||
| DLB – Introduction | |||||
| DLB – Signs and Symptoms | |||||
| DLB – Diagnosis | |||||
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| Prescribing Information |
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Diagnosis
- The major difference between Alzheimer’s disease and DLB is the dopaminergic avaliability.
- In DLB there is a 72% reduction in dopamine concentration in the putamen compared to elderly controls.[3] There is also a 57% reduction in binding to the dopamine uptake sites (presynaptic receptors) in DLB compared to controls. In contrast, binding to these dopamine uptake sites was similar between AD and control patients.[3]
- By imaging the nigrostriatal pathways, DaTSCAN could help distinquish probable DLB from Alzheimer’s disease.[2]
1. Mosimann UP, McKeith IG. Swiss Med Wkly 2003; 133: 131-42
2. Walker Z et al. J Neurol Neurosurg Psychiatry 2002; 73: 134-140
3. Piggot MS et al. Brain 1999; 122: 1449-68
4. Marek K et al. Parkinson's disease: Advances in Neurology; 91: 183-91
2. Walker Z et al. J Neurol Neurosurg Psychiatry 2002; 73: 134-140
3. Piggot MS et al. Brain 1999; 122: 1449-68
4. Marek K et al. Parkinson's disease: Advances in Neurology; 91: 183-91
