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Introduction

Until recently DLB has been difficult to diagnose, and is often misdiagnosed as Alzheimer's disease as many symptoms overlap.[2]

DaTSCAN may assist in distinguishing probable DLB from Alzheimer's disease.[3]

DaTSCAN Comparison of Alzheimer's disease and probable DLB

Images courtesy of Southampton General hospital.

Accurate and early diagnosis of probable DLB is essential for optimal management:[4]

  • severe neuroleptic sensitivity may be avoided
  • a trial of cholinesterase treatment can be instigated
  • Parkinsonian symptoms can be managed appropriately, weighing up the balance of psychiatric and motor symptoms, and falls risk
1 McKeith IG et al. Neurology 1996: 47(5); 1113-24
2 Mosimann UP. McKeith IG. Swiss Med Wkly 2003; 133: 131-42
3 Walker Z et al. J Neurol Neurosurg Psychiatry 2002; 73: 134-140
4 Ballard C et al. J Neurol Neurosurg Psychiatry 2002; 72: 565-66
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